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KMID : 0356919920250040726
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Korean Journal of Anesthesiology
1992 Volume.25 No. 4 p.726 ~ p.732
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A Comparison of Nalbuphine, Morphine and Placebo as Premedication Agents
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이혜원
김재환/강포순/임혜자/채병국/장성호/신정순
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Abstract
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Nabuphine hydrochloride is a new analgesic structurally related to naloxone, a widely used narcotic antagonist, and oxymorphone, a potent narcotic analgesic. Multiple clinical trials have verified the efficacy of nalbuphine in the relief of
moderate to
severe pain. In general, nalbuphine appears equal to morphine in both medical and surgical use at the same dosage levels and route of administration, although nalbuphine has a slightly longer duration of action.
The purpose of this study was to assess the effecacy and side effects of nalbuphine in preoperative medication. Morphine and normal saline as placebo were included for comparison purpose.
Exghty four patients who were scheduled to have an elective operation were included in this randomized, double-blind study. The patients received 0.17 mg kg of nalbuphine. 0.12 mg kg of morphine or 1 ml of normal saline respectively. By
inrramuscular
injection one hour before arriving at operating room. Sedation. Level of anxiety. Emesis, subjective rating on the effect of premedication and side effects were evaluated.
@ES The results were as follows;
@EN 1) The sedation score was significantly lower in nalbuphine group than placebo group.
2) The level of anxiety was significantly lower in nalbuphine and morphine group than placebo group.
3) The frequency of emesis was not significantly different among three groups.
4) In the subjective rating on the effect of premedication. Nalbuphine group was significantly more favorable than placebo group.
5) The side effects such as headache and dizziness were observed, and there were no significant differences in the frequency among three groups.
The results indicate that nalbuphine may be recommended as an effective premedication agent in those situations where opiods are considered as premedication agents.
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